Cellist Tanja Tetzlaff performs an extensive repertoire, including the staple solo and chamber music literature, and important compositions of the 20th and 21st centuries. Tanja Tetzlaff has played with leading orchestras such as the Tonhalle Orchestra Zurich, Bayerischer Rundfunk, Konzerthausorchester Berlin, Deutsche Kammerphilharmonie Bremen, Royal Flanders Philharmonic, Spanish National Orchestra, Orchestre Philharmonique de Radio France, Orchestre de Paris and Cincinnati Symphony Orchestra, and collaborated with conductors such as Lorin Maazel, Daniel Harding, Philippe Herreweghe, Sir Roger Norrington, Vladimir Ashkenazy, Dmitri Kitajenko, Paavo Järvi, Michael Gielen and Heinz Holliger.
Chamber music also plays a significant part in her career, with regular appearances alongside Leif Ove Andsnes, Alexander Lonquich, Antje Weithaas, Florian Donderer, Baiba and Lauma Skride, and her brother, Christian Tetzlaff. In 1994 Tanja founded the Tetzlaff Quartett, with Christian Tetzlaff, Elisabeth Kufferath and Hanna Weinmeister.